BRTE320105
Determination of Fifty Trace Element Contents in Normal and Goitrous Thyroid using a Combination of Instrumental Neutron Activation Analysis and Inductively Coupled Plasma Mass Spectrometry
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- Determination of Fifty Trace Element Contents in Normal and Goitrous Thyroid using a Combination of Instrumental Neutron Activation Analysis and Inductively Coupled Plasma Mass Spectrometry
Vladimir Zaichick
Received: Jun 10, 2021
Accepted: September 10, 2021
Released online: October 15, 2021
Abstract
Background: Nodular goiter (NG) is an internationally important health problem. The aim of this exploratory study was to evaluate whether significantchanges in the thyroid tissue levels of fifty trace elements (TE) exist in the goitrous transformed thyroid.
Method: Thyroid tissue levels of fifty TE were prospectively evaluated in 46 patients with colloid NG and 105 healthy inhabitants. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma mass spectrometry, respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis.
Results: It was found that contents of Ag, Al, Bi, Ce, Cr, Er, Fe, Hg, La, Li, Mn, Mo, Nd, Ni, Pr, Se, Sm, Tl, U, Y, and Zn in colloid NG tissue significantly increased whereas the levels of Cd, Ga, and Sn decrease in comparison with those in normal thyroid.